Time of withdrawal / Caffeine / theobromine / paraxanthine / Collovet / camel / horse / greyhound

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Withdrawal Times

Collovet contains caffeine. Caffeine or its metabolites are present in

tea leaves, coffee beans, cocoa products and many cola soft drinks

and human tonic drinks.

Horses take longer to excrete caffeine than humans.

In animals caffeine is metabolised into theobromine and paraxanthine.

All these chemicals are classed as stimulants and most racing and

equestrian jurisdictions throughout the world subject them to “zero

tolerance”. This is the situation in Australia.

This means there should be no trace of these substances in any

samples taken from the animal prior to or after the running of a race

or competing in competitions.

Caffeine has the following effects:

· Increases mental alertness

· Reduces mental fatigue

· Increases central nervous system stimulation

· Temporarily increases the capacity for work or performance

· Affects cardio vascular system

· Affects respiratory system

Caffeine is quickly absorbed from the stomach and intestinal

tract after oral dosing. It is excreted via the urine after undergoing

metabolism in the liver and kidneys.

Theobromine is the major excretion metabolite of caffeine.

Studies have shown that 3% of a caffeine dose in a horse is

eliminated unchanged within 24 hours of the first dose.
The remaining caffeine is excreted after being metabolised to
mainly theobromine over an extended period.

There are many factors that influence the time it will take to
clear caffeine from the animal system. These include but are not
limited to:

The total dose administered to the animal

The cumulative effect of multiple doses

The individual animals health and diet

Other medications being used by the animal.

Environmental contamination. There have been cases caused by contact with the bedding of the stable. Especially if the stable is

not carefully and regularly cleaned after dosing with a substance

containing caffeine.

It is generally accepted that the withdrawal period for caffeine
is about 10 -12 days. However this figure will vary with the
animal and trainers and riders should always be conservative by
allowing ample time for complete elimination.

To illustrate there was a reported case where horses were fed chocolate

coated peanuts. It took 14 days before caffeine and its metabolites were

excreted from the system.

If you use substances containing caffeine it is
recommended you discuss the withdrawal time with your
veterinarian.

Note:

As the use of Collovet is beyond the control of the manufacturer the user

takes full responsibility for any result however occurring.

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